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Tokyo, It is common knowledge that people who are obese are prone to diabetes, heart attack, and stroke. Not only that, obesity can also increase the risk of some types of cancer such as cancer of the esophagus, colorectal, pancreatic, and other cancers.
The researchers found a correlation between obesity and the likelihood of a person developing liver cancer. Obesity causes significant changes in the microbes living in the gut. Changes in the microbes to stimulate existing bacteria release chemicals that damage DNA and cause tumor progression.
Written in the journal Nature, a team of researchers led by Eiji Hara of the Japanese Foundation for Cancer Research in Tokyo explains how they induce cancer in mice by giving newborn pups with carcinogens. Carcinogen known to produce various types of tumors.
Then, they gave half of the rats eating a normal diet and the other half with the high-fat diet. All mice fed a high-fat diet, liver cancer cells growing. While mice on a normal diet did not. Separately, researchers also gave a carcinogen in mice that are genetically obese and they are not given a high-fat diet. As a result, the cancer cells spread well. This suggests that obesitaslah that cause cancer, not diets fed to rats.
The research team also uses the signal to track bioluminscent chemicals in mice that causes the cell closures as the network age. Found that mice with a greater risk of liver cancer, contain more chemicals such. Cancer is also associated with dementia.
Researchers found certain bacteria in obese mice. In subsequent experiments, the bacteria secreted with bile acids and produce deoxycholic acid (DCA), which can damage DNA and create a senile person.
Giving antibiotics to eliminate microbial DCA shown to reduce the risk of liver cancer. "It is clear that the increased production of DCA caused by intestinal bacteria that is closely linked to obesity and liver cancer," write the authors of the study, as reported by the LA Times, Tuesday (09/07/2013).
In an editorial accompanying the study, Harvard researchers, Suzanne Devkota and Peter J. Turnbaugh said that Japanese scientists found a reasonable relationship between DCA and liver cancer. "Metabolism of bile acids and microbes can create a mechanism that resulted in disaster for our health, and it all resulted from our behavior at the dinner table," they wrote.
The study also shows how the microbes living in the human body affects health for the better or worse.
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